Assessment of the Effectiveness of Omicron Transmission Mitigation Strategies for European Universities Using an Agent-Based Network ModelArticle Published on 2022-12-192023-07-09 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), [키워드] agend-based COVID-19 modeling network. prevention [DOI] 10.1093/cid/ciac340 PMC 바로가기
Population-wide measures due to the COVID-19 pandemic and exposome changes in the general population of Cyprus in March-May 2020Article Published on 2022-12-062023-07-11 Journal: BMC Public Health [Category] COVID19(2023년), [키워드] exposome exposures Measures modeling pandemic. [DOI] 10.1186/s12889-022-14468-z PMC 바로가기
Modeling studies on the role of vitamins B1 (thiamin), B3 (nicotinamide), B6 (pyridoxamine), and caffeine as potential leads for the drug design against COVID-19Article Published on 2022-11-072022-11-15 Journal: Journal of molecular modeling [Category] SARS, 신약개발, 치료제, [키워드] ACE-2 adopted Antiviral antiviral activity applied approach binding pocket binding site caffeine Cell Characteristics chemical property Compound COVID-19 COVID-19 pandemic docking domain dosage drug design effective evaluate function impair Interaction Invasion lack mechanism modeling molecular molecular dynamic simulations Neutral nicotinamide potential mechanism Protein pyridoxamine Safe SARS-CoV-2 selected Side effects Structural analysis Structure the SARS-CoV-2 the Spike thiamin Toxicity Vitamin Vitamin B. [DOI] 10.1007/s00894-022-05356-9 PMC 바로가기
SARS-CoV-2 Spike-Binding Antibody Longevity and Protection from Reinfection with Antigenically Similar SARS-CoV-2 VariantsArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome advanced age analyzed antibodies antibody antibody durability Antibody titer circulation Cohort collected convalescent coronavirus coronavirus disease COVID-19 decrease detectable determine Effectiveness Enrollment exceptional female Health care worker highlight immune responses Increases Infection initial limit Longevity median modeling mounted new SARS-CoV-2 occurred Pandemics participant Participants protection public health crisis Rapid Reinfection risk SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 variant seronegative seropositive seropositive participant severe COVID-19 Sex spike-binding antibodies. stability Steady state vaccination variants of concern viruses [DOI] 10.1128/mbio.01784-22 PMC 바로가기
SUMMIT: An integrative approach for better transcriptomic data imputation improves causal gene identificationArticle Published on 2022-10-252022-11-16 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] Accuracy analysis approach association Blood build complex component COVID-19 severity dataset eQTL etiology explain expression Gene Expression Genetic Genome-wide association study identify IMPROVE loci low expression modeling moderate proportion provided Quantitative regulated severity Simulation study Statistical power traits transcriptome-wide transcriptomic data with COVID-19 [DOI] 10.1038/s41467-022-34016-y PMC 바로가기
A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivoArticle Published on 2022-10-182022-11-15 Journal: Cell Reports Medicine [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] ACE2 acute respiratory syndrome Administered Antiviral antiviral activity association atomic Atomic force microscopy banana binding binding site cellular component concentrations conserved coronavirus coronavirus effective experiment glycan healthy high affinity high-mannose human cells identify in vivo inhibit intranasally intraperitoneally lack lectin MERS-CoV MERS-CoV infection Microscopy Middle East modeling omicron PROTECT recognize resistant mutants respiratory syndrome coronavirus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike single-molecule force spectroscopy spike spike trimer target the SARS-CoV-2 Treatment Treatment. Viral protein virus entry [DOI] 10.1016/j.xcrm.2022.100774 PMC 바로가기
Global-scale modeling of early factors and country-specific trajectories of COVID-19 incidence: a cross-sectional study of the first 6 months of the pandemicObservational Study Published on 2022-10-142023-07-10 Journal: BMC Public Health [Category] COVID19(2023년), [키워드] Clustering COVID-19 Factors Global lockdown modeling Regression. [DOI] 10.1186/s12889-022-14336-w PMC 바로가기 [Article Type] Observational Study
Susceptibility to Resurgent COVID-19 Outbreaks Following Vaccine Rollouts: A Modeling StudyArticle Published on 2022-10-122022-11-16 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] affecting Asymptomatic Characteristics compartmental model conditions contagious country Coverage COVID-19 COVID-19 vaccine COVID-19 vaccines Effect Effectiveness Endemic Epidemics epidemiological expand explain Health help Immunity include initial key factor modeling parameter populations reported resurgent epidemics SARS-CoV-2 SARS-CoV-2 variants Spread susceptibility the disease the SARS-CoV-2 virus the vaccine vaccination vaccination coverage waning immunity Waning Immunity. [DOI] 10.3390/v14102237 PMC 바로가기
Modeling the Effectiveness of Healthcare Personnel Reactive Testing and Screening for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Omicron Variant Within Nursing HomesArticle Published on 2022-10-032022-11-16 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), SARS, 변종, [키워드] acute infection Antigen clearance Concentration coronavirus 2 coronavirus disease COVID-19 evade Factor faster healthcare personnel home Immune escape Immunity impacted index case Infection modeling Nursing nursing homes omicron outbreak outbreak testing positive Prevent provide reduction in representing respiratory SARS-CoV-2 Screening screening testing. sensitivity Testing Transmission vaccination variant variants viral shedding [DOI] 10.1093/cid/ciac505 PMC 바로가기
Vaccine models predict rules for updating vaccines against evolving pathogens such as SARS-CoV-2 and influenza in the context of pre-existing immunityArticle Published on 2022-10-032022-11-16 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] Affect Analysis approach benefit circulating variant circulating variants complex COVID-19 dissect H5N1 Immunity individuals induce influence Influenza influenza virus modeling omicron pathogen pre-existing immunity predict recall response SARS-CoV-2 SARS-CoV-2 vaccine Simulations Vaccine Vaccines variants variants. [DOI] 10.3389/fimmu.2022.985478 PMC 바로가기